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Zinc-containing alkaline phosphatase
(1alk) enzyme from Escherichia coli
What structural elements
are present?
What is the subunit composition
of the proteins?
What are the major features
of the active site?
What is the distance between
metal centers?
Kim, E. E., Wyckoff, H. W. 1991. Reaction mechanism of alkaline phosphatase
based on crystal structures. Two-metal ion catalysis. J. Mol.
Biol. 218:449-464.
Alkaline phosphatase (1alk)
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Asp51, Asp327, Asp369, Glu322, His331,
His370, His412, Ser102, Thr155, one phosphate and one water molecule