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Eric C. Niederhoffer, Ph.D.

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Lac repressor in the absence (1lbh) and presence of DNA (efa) from Escherichia coli

Lewis, M., G. Chang, N. C. Horton, M. A. Kercher, H. C. Pace, M. A. Schumacher, R. G. Brennan, and P. Lu. 1996. Crystal structure of the lactose operon repressor and its complexes with DNA and inducer. Science 271:1247-1254.

Bell, C. E., and M. Lewis. 2000. A closer view of the conformation of the Lac repressor bound to operator. Nat. Struct. Biol. 7:209-214.

Lac repressor (1lbh)

Lac repressor with DNA (1efa)

Alternate View

  • Push the button  to observe one monomeric unit and the following residues within 3.0 Å of the inducer isopropyl-1-b-D-thiogalactoside (IPTG):
Arg197, Asp274

Push button  for Original View

Alternate View

  • Push the button  to observe one monomeric unit and the following residues within 3.0 Å of RNA:
Ala57, Arg22, Asn25, Gln18, Gln54, Leu6, Ser16, Ser21, Tyr17, Tyr47

Push button  for Original View

 

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