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Eric C. Niederhoffer, Ph.D.

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Iron-dependent regulator (1b1b, 1fx7) from Mycobacterium tuberculosis

Pohl, E., R. K. Holmes, and W. G. J. Hol. 1999. Crystal structure of the iron-dependent regulator (Ider) from Mycobacterium tuberculosis shows both metal binding sites fully occupied. J. Mol. Biol. 285:1145-1156.

Feese, M. D., B. P. Ingason, J. Goranson-Siekierke, R. K. Holmes, and W. J. G. Hol. 2001. Crystal structure of the iron-dependent regulator from Mycobacterium tuberculosis at 2.0-Å resolution reveals the Src homology domain 3-like fold and metal binding function of the third domain. J. Biol. Chem. 276:5959-5966.

Iron-dependent regulator (1b1b)

Iron-dependent regulator (1fx7)

Alternate View

  • Push the button  to observe the following residues within 3.0 Å of the Zn2+ centers:
Cys102, Glu83, Glu105, His79, His98, His106, Met10, one sulfate, and one water ligand

Push button  for Original View

Alternate View

  • Push the button  to observe the following residues within 3.0 Å of the predicted metal sites:
Cys102, Glu83, Glu105, His79, His98, His106, Met10

Push button  for Original View

 

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