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Yeast (Saccharomyces cerevisiae) copper chaperone for Sod (1qup), human copper chaperone for Sod (1do5), and human copper,zinc-superoxide dismutase (1spd)

• What structural elements are present in each molecule?
• What is the subunit composition?
• What comparisons exist with the structures?

Lamb, A. L., A. K. Wernimont, R. A. Pufahl, T. V. O'Halloran, and A. C. Rosenzweig. 1999. Crystal structure of the copper chaperone for superoxide dismutase Nat. Struct. Biol. 6:724-729.

Lamb, A. L., A. K. Wernimont, R. A. Pufahl, T. V. O'Halloran, and A. C. Rosenzweig. 2000. Crystal structure of the second domain of the human copper chaperone for superoxide dismutase. Biochemistry 39:1589-1595.

Deng, H. X., A. Hentati, J. A. Tainer, Z. Iqbal, A. Cayabyab, W. Y. Hung, E. D. Getzoff, P. Hu, B. Herzfeldt, R. P. Roos, C. Warner, G. Deng, E. Soriano, C. Smyth, H. E. Parge, A. Ahmed, A. D. Roses, R. A. Hallewell, M. A. Pericak-Vance, and T. Siddique. 1993. Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase. Science 261:1047-1051.

Static Images Only, Please Install the Chime Plug-In. Yeast copper chaperone for Sod (1qup)

Static Images Only, Please Install the Chime Plug-In. Human copper chaperone for Sod (1do5)

Static Images Only, Please Install the Chime Plug-In. Copper,zinc superoxide dismutase (1spd)

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