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Eric C. Niederhoffer, Ph.D.

Ecnhoffer@chimesquare.com
Copyright 2000- , E.C. Niederhoffer.
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Manganese-containing arginase (1rla) from Rattus norvegicus (rat) and the nickel-containing urease (1fwj) from Klebsiella aerogenes

Kanyo, Z. F., L. R. Scolnick, D. E. Ash, and D. W. Christianson. 1996. Structure of a unique binuclear manganese cluster in arginase. Nature 383:554557.

Pearson, M. A., L. O. Michel, R. P. Hausinger, and P. A. Karplus. 1997. Structures of Cys319 variants and acetohydroxamate-inhibited Klebsiella aerogenes urease. Biochemistry 36:8164-8172.

Arginase (1rla)

Urease (1fwj)

Active Site View

  • Push the button  to observe the following residues within 3.0 Å of the binuclear manganese site:
Asp124, Asp128, Asp232, Asp234, His101, His126, and one water molecule

Push button  for Original View

Active Site View

  • Push the button  to observe the following residues within 3.0 Å of the binuclear nickel site:
Asp360, His134, His136, His246, His272, Lys217 (carbamylated), and three water molecules

Push button  for Original View

 

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