[NiFeS] Carbon monoxide dehydrogenase structure

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Eric C. Niederhoffer, Ph.D.

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Carbon monoxide dehydrogenase (1jjy) from Carboxydothermus hydrogenoformans

One monomer is presented.

What structural elements are present?
What is the subunit composition of the proteins?
How many metal-sulfur clusters are present?
What are the major features of the active site?
What is the distance between metal centers?
What is the most likely electron transfer pathway? Recall that the enzyme is a dimer.

Dobbek, H., V. Svetlitchnyi, L. Gremer, R. Huber, and O. Meyer. 2001. Crystal structure of a carbon monoxide dehydrogenase reveals a [Ni-4Fe-5S] cluster. Science 293:1281-1285.

Carbon monoxide dehydrogenase (1jjy)

Active Site Views

Push the button to observe the following residues within 3 Å of the iron-sulfur clusters:

Cys39, Cys47, Cys48, Cys51, Cys56, Cys70, Cys295, Cys333, Cys446, Cys476, Cys526, His261 and one water molecule

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Molecular Graphics Resource

Eric C. Niederhoffer, Ph.D.

One monomer is presented.

Carbon monoxide dehydrogenase (1jjy)

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