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Eric C. Niederhoffer, Ph.D.
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Carbon monoxide dehydrogenase
(1jjy) from Carboxydothermus hydrogenoformans
One monomer is presented.
- What structural elements
are present?
- What is the subunit composition
of the proteins?
- How many metal-sulfur clusters
are present?
- What are the major features
of the active site?
- What is the distance between
metal centers?
- What is the most likely electron
transfer pathway? Recall that the enzyme is a dimer.
Dobbek, H., V. Svetlitchnyi, L. Gremer,
R. Huber, and O. Meyer. 2001.
Crystal structure of a carbon monoxide dehydrogenase reveals a
[Ni-4Fe-5S] cluster. Science 293:1281-1285.
Carbon monoxide dehydrogenase (1jjy)
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