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Phosphoglycerate kinase (13pk) from
Trypanosoma brucei
What structural elements
are present in each molecule?
What is the subunit composition?
Which residues are most likely
to participate as general acid and base catalysts?
Bernstein, B. E., P. A. Michels, and
W. G. Hol. 1997. Synergistic
effects of substrate-induced conformational changes in phosphoglycerate
kinase activation. Nature 385:275-278.
Phosphoglycerate kinase (13pk)
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Ala218, Ala314, Ala400, Arg39, Arg65,
Arg135, Arg172, Asn26, Asn338, Asp24, Asp377, Glu345, Gly168,
Gly376, Gly398, Gly399, His62, Leu315, Lys223, Ser378, and nine
water molecules