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Eric C. Niederhoffer, Ph.D.

Ecnhoffer@chimesquare.com
Copyright 2000- , E.C. Niederhoffer.
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Open (1ig8) and closed (1hkg) forms of hexokinase from Saccharomyces cerevisiae

The open form allows binding of glucopyranose and ATP while the closed form excludes water from the active site in preparation for the catalytic reaction.

Kuser, P. R., S. Krauchenco, O. A. Antunes, and I. Polikarpov. 2000. The high resolution crystal structure of yeast hexokinase Pii with the correct primary sequence provides new insights into its mechanism of action. J. Biol. Chem. 275:20814-20821.

Steitz, T. A., M. Shoham, and W. S. Bennett Jr. 1981. Structural dynamics of yeast hexokinase during catalysis. Philos. Trans. R. Soc. Lond. B Biol. Sci. 293:43-52.

Hexokinase open form (1ig8)

Hexokinase closed form (1hkg)

Active Site View

  • Push the button  to observe the following residues near the glucose binding site:
Asp211, Asn237, Glu269, Glu302, Lys176, Ser158, Thr175

Hydrophobic Channel View

  • Push the button  to observe the following residues lining a hydrophobic channel:
Ile85, Ile131, Ile196, Leu87, Leu127, Leu135, Leu153, Leu192, Met191, Phe155, Phe157, Phe178

Push button  for Original View

Active Site View

  • Push the button  to observe the following residues near the glucose binding site:
Asp189, Asn215, Unk245, Glu277, Unk156, Ser190

Hydrophobic Channel View

  • Push the button  to observe the following residues lining a hydrophobic channel:
Ile67, Ile151, Ile167, Leu65, Leu74, Leu133, Leu160, Leu163, Leu166, Met69, Met99, Phe135, Phe137, Phe158

Push button  for Original View

 

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