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Molecular Graphics Resource

Eric C. Niederhoffer, Ph.D.

Ecnhoffer@chimesquare.com
Copyright 2000- , E.C. Niederhoffer.
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Human erythrocyte hemoglobin in the deoxy (1a3n) and oxy (1thb) states

Waller, D. A., and R. C. Liddington. 1990. Refinement of a partially oxygenated T state human haemoglobin at 1.5 Å resolution. Acta Crystallogr. B 46:409-418.

Hemoglobin (1a3n) deoxy

Hemoglobin (1thb) oxy

Active Site Views

  • Push the button  to observe the following residues near the iron center:
His58, His87
  • Push the button  to observe structural changes near the heme center:
His58, His87, Leu83, Leu91, Leu101, Leu136, Phe43, Phe98, Val62
  • Push the button  to observe interactions between alpha1-beta2 interface:
Asn102, Asp94, Asp99, His97, Tyr42
  • Push the button  to observe hydrogen bonds and ion pairs in alpha chains:
Arg141, Asp126, Lys127, Tyr140, Val1, Val34, Val93
  • Push the button  to observe hydrogen bonds and ion pairs in beta chains:
Asp94, His146, Lys40, Tyr145, Val98
  • Push the button  to observe 2,3-bisphosphoglycerate binding site:
His2, His143, Lys82 (Val1 missing)

Push button  for Original View

Active Site Views

  • Push the button  to observe the following residues near the iron center:
His58, His87, and one dioxygen ligand
  • Push the button  to observe structural changes near the heme center:
His58, His87, Leu83, Leu91, Leu101, Leu136, Phe43, Phe98, Val62, and one dioxygen ligand
  • Push the button  to observe interactions between alpha1-beta2 interface:
Asn102, Asp94, Asp99, His97, Tyr42
  • Push the button  to observe hydrogen bonds and ion pairs in alpha chains:
Arg141, Asp126, Lys127, Tyr140, Val1, Val34, Val93
  • Push the button  to observe hydrogen bonds and ion pairs in beta chains:
Asp94, His146, Lys40, Tyr145, Val98
  • Push the button  to observe 2,3-bisphosphoglycerate binding site:
His2, His143, Lys82 (Val1 missing)

Push button  for Original View

 

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