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Aconitase in the inactive (5acn) form from Sus scrofa (pig) and active forms (1c96, 1c97) from Bos taurus (bovine)

• What structural elements are present in each molecule?
• What is the subunit composition?
• What is the distance between metal centers?
• What is the coordination geometry about each metal ion?
• What are the changes that occur upon activation and binding of citrate and isocitrate?

Robbins, A. H., and C. D. Stout. 1989. Structure of activated aconitase: formation of the [4Fe-4S] cluster in the crystal. Proc. Natl. Acad. Sci. U.S.A. 86:3639-3643.

Lloyd, S. J., H. Lauble, G. S. Prasad, and C. D. Stout. 1999. The mechanism of aconitase: 1.8 Å crystal structure of the S642A: citrate complex. Protein Sci. 8:2655-2662.

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